The Dhyana400BSI achieves a key technological breakthrough in back-illuminated sCMOS, with a readout noise of less than 1 electron using CMS processing technology. This causes an unparalleled advantage with respect to the signal-to-noise ratio. With the built-in signal enhancement alogrithm the S/N ratio can be further improved. The Dhyana 95 is a 2048 x 2048 pixel, 24 fps sCMOS camera with a quantum efficiency of 95% at 560nm. Featuring a readout noise of 1.45e, this camera represents the first real challenge to EMCCD cameras, but with a much higher resolution. With an 11 micron pixel, this camera is a great fit in super resolution and high speed confocal systems, enabling higher level of productivity than previously possible.